Sirtuins are a family of proteins that play a crucial role in regulating cellular processes, metabolism and ageing. These proteins,
particularly SIRT1-7, are involved in maintaining cellular homeostasis (balance) by influencing gene expression, DNA repair, and stress response pathways. Sirtuins are particularly notable for their involvement in the cellular response to calorie restriction, a dietary regimen that has been linked to increased lifespan. When nutrients are limited, Sirtuins are activated to optimize energy usage, improve mitochondrial function, and promote cellular resilience. This activation is thought to mimic the effects of calorie restriction, contributing to a slower ageing process and increased longevity.

Moreover, Sirtuins play a crucial role in regulating the activity of other proteins, including those associated with cellular senescence and inflammation. By influencing these processes, Sirtuins can impact the rate of ageing and age-related diseases. Research continues to explore the therapeutic applications of Sirtuin activators, like NMN (Nicotinamide
Mononucleotide), NR (Nicotinamide Riboside), Fisetin and Quercetin, for their role in extending lifespan and improving overall health.